MEK-IN-5

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MEK-IN-5 

MEK-IN-5 是一种有效的 MEK 抑制剂和 NO 供体。MEK-IN-5 以剂量和时间依赖性方式显著降低 pMEK 和 pERK 的表达水平。MEK-IN-5 诱导 MDA-MB-231 细胞凋亡 (apoptosis)。

MEK-IN-5

MEK-IN-5 Chemical Structure

CAS No. : 2417022-06-9

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生物活性

MEK-IN-5 is a potent MEK inhibitor and NO donor. MEK-IN-5 significantly reduces the levels of pMEK and pERK in a dose-dependent and time-dependent manner. MEK-IN-5 induces apoptosis in MDA-MB-231 cells[1].

体外研究
(In Vitro)

MEK-IN-5 (compound 18h) shows anti-proliferation activities for different tumor cells and low toxicity for normal cells[1].
MEK-IN-5 (0.1, 1, 10 µM; 1, 2, 4, 6 h) decreases the expression level of pMEK and pERK in a dose-dependent and time-dependent manner[1].
MEK-IN-5 (1, 10 µM; 24 h) induces apoptosis in MDA-MB-231 cells[1].
MEK-IN-5 (100 µM; 2h) significantly induce NO release in HCT116 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231, HCT116, A549, Vero, HL7702 cells
Concentration:
Incubation Time:
Result: Showed anti-proliferation activities in MDA-MB-231, HCT116, A549, Vero, HL7702 cells with IC50s of 0.034, 0.64, 1.35, 21.07, 5.62 µM, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 1, 10 µM
Incubation Time: 1, 2, 4, 6 h
Result: Decreased the expression level of pMEK and pERK in a dose-dependent and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 1, 10 µM
Incubation Time: 24 h
Result: Induced apoptosis in MDA-MB-231 cells.

分子量

674.67

Formula

C29H27FN4O10S2
CAS 号

2417022-06-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wang C, et al. Hybrids of MEK inhibitor and NO donor as multitarget antitumor drugs. Eur J Med Chem. 2020; 196:112271.

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