Steroid sulfatase-IN-1

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Steroid sulfatase-IN-1 

Steroid sulfatase-IN-1 是一种有效的且具有口服活性的 Steroid sulfatase 抑制剂，IC50 为 1.71 µM。Steroid sulfatase-IN-1 在体内发挥抗肿瘤作用 (TGI=51%)。Steroid sulfatase-IN-1 具有乳腺癌研究潜力。

Steroid sulfatase-IN-1

Steroid sulfatase-IN-1 Chemical Structure

CAS No. : 2403716-19-6

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生物活性

Steroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 µM. Steroid sulfatase-IN-1 shows antitumor activity (TGI=51%) in vivo. Steroid sulfatase-IN-1 has the potential for the research of breast cancer[1].

IC50 & Target

IC50: 1.71 µM (Steroid sulfatase)[1]
体内研究
(In Vivo)

Steroid sulfatase-IN-1 (compound 4 b) (50 mg/kg; p.o.) shows significant antitumor activity with the TGI value of 51%[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 67NR mouse[1]
Dosage: 50 mg/kg
Administration: P.o.
Result: Showed significant antitumor activity with the TGI value of 51%.

分子量

385.23

Formula

C14H10Cl2N4O3S
CAS 号

2403716-19-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Biernacki K, et al. Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. J Med Chem. 2022; 65(6):5044-5056.

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