CS1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CS1 

CS1 是一种有效的 DNA Topo II 抑制剂。CS1 具有广谱的体外抗肿瘤作用、体内低毒性和潜在的抗多药耐药能力。CS1 导致 DNA 损伤、细胞周期停滞在 G2/M 期和细胞凋亡apoptosis。

CS1

CS1 Chemical Structure

CAS No. : 1448009-94-6

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生物活性

CS1 is a potent DNA Topo II α inhibitor. CS1 displays broad-spectrum in vitro antitumor effects, low toxicity in vivo and potential anti-multidrug resistance capabilities. CS1 leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis[1].

IC50 & Target

topoisomerase II alpha

 

体外研究
(In Vitro)

CS1 shows cytotoxicity with IC50 values of 16.92 and 18.88 µM for MCF-7 and MCF7/ADR cells, respectively[1]
. CS1 (10, 50, 100 µM) inhibits the activity of topoisomerase II α (Topo IIα)[1].
CS1 (0-20 µM) shows antiproliferation activity in cancer cells[1].
CS1 (2.5, 5, 10 µM) induces cell cycle arrest at the G2/M phase[1].
CS1 (2.5, 5, 10 µM) induces cell apoptosis[1].
CS1 (5, 10, 15 µM; 24 h) induces DNA breaks in MDA-MB-231 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10 µM
Incubation Time:
Result: Cells were arrest at the G2/M phase.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 2.5, 5, 10 µM
Incubation Time:
Result: Induced apoptosis

体内研究
(In Vivo)

CS1 (20 mg/kg; i.v.; every other day for two weeks) shows antitumor effects[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old female athymic nude mice (BALB/c-nu)[1]
Dosage: 20 mg/kg
Administration: i.v., every other day for two weeks
Result: Showed antitumor effects.

分子量

252.26

Formula

C16H12O3
CAS 号

1448009-94-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shen Y, et al. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles. Biochem Biophys Res Commun. 2014; 453(3):302-8.

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