TNIK-IN-5 is an efficient TNIK inhibitor with IC₅₀ of 0.05 μM. TNIK-IN-5 efficiently inhibits Wnt signaling in intact cells. TNIK-IN-5 shows excellent in vitro anti-colorectal cancer activity^[1].

IC₅₀: 0.05 μM (TNIK)^[1]

TNIK-IN-5 (compound 8g) (1.25-5 μM; 48 hours) significantly inhibits the cell proliferation of HCT116 in a dose-dependent manner^[1].
TNIK-IN-5 (1 μM; 24, 48 hours) strongly prevents HCT116 cells migration^[1].
TNIK-IN-5 (10-40 μM; 48 hours) concentration-dependently inhibits the protein levels of β-catenin and TCF-4 in the nucleus, and significantly decreases the expression of Wnt target gene products, including Axin2 and c-Myc^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

371.39

C₂₂H₁₇N₃O₃

2754265-66-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745.