Antitumor agent-43

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antitumor agent-43 

Antitumor agent-43 (Compound 4B) 是一种抗肿瘤剂，对 T-24 细胞的IC50值为0.5 µM. Antitumor agent-43 (Compound 4B)诱导细胞周期阻滞在G2/M期。

Antitumor agent-43

Antitumor agent-43 Chemical Structure

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生物活性

Antitumor agent-43 (Compound 4B) is a potent antitumor agent, with an IC50of 0.5 µM for (T-24 cell). Antitumor agent-43 (Compound 4B) induces cell cycle arrest at G2/M phase[1].

体外研究
(In Vitro)

Antitumor agent-43 towards T-24, MGC80-3, SK-OV-3, HepG2 cells with IC50of 0.5, 1.1, 8.9 and 1.3µM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Antitumor agent-43 effectively inhibits tumor growth (49.5%) in a mouse xenograft model bearing T-24. [1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

276.25

Formula

C16H8N2O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lan-Shan Liao, et al. One-pot synthesis of oxoaporphines as potent antitumor agents and investigation of their mechanisms of actions. Eur J Med Chem

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