Vacquinol-1(Synonyms: NSC13316) | whatman (沃特曼)

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Vacquinol-1 (Synonyms: NSC13316)

Vacquinol-1 (NSC13316) 是一种 MKK4 特异性激活剂，可激活 MAPK 通路。 Vacquinol-1 在多形性胶质母细胞瘤 (GBM) 小鼠模型中特异性诱导人胶质母细胞瘤细胞 (GC) 死亡、减缓肿瘤进展并延长生存期。 Vacquinol-1 还诱导肝细胞癌 (HCC) 细胞凋亡。

Vacquinol-1 Chemical Structure

CAS No. : 5428-80-8

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

Vacquinol-1 (NSC13316) is a MKK4-specific activator that activates MAPK pathways^[1]. Vacquinol-1 specifically induces human glioblastoma cell (GC) death, attenuates tumor progression and prolongs survival in a glioblastoma multiforme (GBM) mouse model^[2]. Vacquinol-1 also induces apoptosis in hepatocellular carcinoma (HCC)cell^[3].

分子量

352.86

Formula

C₂₁H₂₁ClN₂O

CAS 号

5428-80-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

DMSO : 30 mg/mL (85.02 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8340 mL	14.1699 mL	28.3399 mL
5 mM	0.5668 mL	2.8340 mL	5.6680 mL
10 mM	0.2834 mL	1.4170 mL	2.8340 mL

参考文献

[1]. Sun SL, Li X, Su N, et al. Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018;18(1):557-563.

[2]. Sander P, Mostafa H, Soboh A, et al. Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP. Oncotarget. 2017;8(21):35124-35137.

[3]. Chao Wu, et al. Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad2/3 at linker regions in vivo and in vitro. Life Sci. 2019 Dec 15;239:116881.

[4]. Yufeng Shi, et al. The soft underbelly of tumor cells. Cell Res. 2014 Aug;24(8):910-1.

[5]. Shu-Lan Sun, et al. Vacquinol 1 induces apoptosis in hepatocellular carcinoma cell. Mol Med Rep. 2018 Jul;18(1):557-563.

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