Anticancer agent 43

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Anticancer agent 43 

Anticancer Agent 43 是一种有效的抗癌剂。Anticancer Agent 43 通过 caspase 3， PARP1，Bax 蛋白依赖性途径诱导凋亡 (apoptosis)。Anticancer Agent 43 能够诱导 DNA 损伤。

Anticancer agent 43

Anticancer agent 43 Chemical Structure

CAS No. : 2470015-35-9

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生物活性

Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage[1].

IC50 & Target[1]

Caspase 3

 

PARP1

 

Bax

 

体外研究
(In Vitro)

Anticancer agent 43 (compound 3a) shows selectivity toward human tumor cells (SI50=28.94)[1].
Anticancer agent 43 (45 µM, 24 h) induces apoptosis via caspase 3, PARP1 and Bax dependent pathways in HepG2 cells[1].
Anticancer agent 43 (45 µM, 24 h) shows no effect on the transition of G1/S phases in HepG2 cells[1].
Anticancer agent 43 (0.7, 45, 55 µM) induces DNA damage in HCT116 cells (Tail DNA=16.1%, OTM=3.7), MCF-7 cells, HepG2 cells (Tail DNA=26.2%, OTM=13.2), Balb/c 3T3 cells (Tail DNA = 8.4%, OTM = 3.5)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: HepG2, MCF-7, HCT116, HeLa, A549, WM793, THP-1, HaCaT, Balb/c3T3 cells
Concentration: 0, 1, 10, 100 µM
Incubation Time: 72 h
Result: Showed cytotoxic action with GI50s of 12.1, 0.7, 0.8, 49.3, 9.7 µM for for HepG2, MCF-7, HCT116, HeLa, A549 cells, low toxicity towards WM793, THP-1, HaCaT, Balb/c 3T3 cells with GI50s of 80.4, 62.4,98.3,40.8 µM , respectively.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 45 µM
Incubation Time: 24 h
Result: Induced apoptosis in HepG2 cells via caspase 3, PARP1 and Bax dependent pathways.

Western Blot Analysis[1]

Cell Line: HCT116, MCF-7 cells
Concentration: 0.7 µM
Incubation Time: 24 h
Result: Decreased the expression of Cdk2 protein in HCT116 and MCF-7 cells.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 45 µM
Incubation Time: 24 h
Result: Showed no effect on the transition of G1/S phases in HepG2 cells.

分子量

336.36

Formula

C14H9FN2O3S2
CAS 号

2470015-35-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kryshchyshyn-Dylevych A, et al. Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential. Bioorg Med Chem. 2021; 50:116453.

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