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Apaziquone (Synonyms: EO-9; NSC 382 459)
Apaziquone (EO-9) 是丝裂霉素 C (Mitomycin C) 的类似物，是一种前药，可被氧化还原酶(尤其是 NQO1) 激活产生 DNA 损伤。Apaziquone 具有杀死需氧和/或缺氧癌细胞的能力。Apaziquone 是一种生物还原性烷化剂，可抑制口腔鳞状细胞癌 (OSCC) 细胞的细胞增殖并诱导细胞凋亡。Apaziquone 显着减少免疫功能低下的 NOD/SCID/Crl 小鼠的口腔肿瘤异种移植物体积。
Apaziquone Chemical Structure
CAS No. : 114560-48-4
| 规格 | 是否有货 | ||
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| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
Apaziquone (EO-9), an analog of Mitomycin C, is a prodrug that is activated to DNA damaging species by oxidoreductases (particularly NQO1). Apaziquone has the ability to kill aerobic and/or hypoxic cancer cells. Apaziquone, a bioreductive alkylating agent, inhibits cell proliferation and induces apoptosis in oral squamous cell carcinoma (OSCC) cells. Apaziquone significantly reduces oral tumor xenograft volume in immunocompromised NOD/SCID/Crl mice[1][2]. |
|---|---|
| 分子量 |
288.30 |
| Formula |
C15H16N2O4 |
| CAS 号 |
114560-48-4 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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