Aurora/LIM kinase-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aurora/LIM kinase-IN-1 

Aurora/LIM 激酶-IN-1 (Compound F114) 是一种有效的 aurora 和 lim 激酶的双重抑制剂。Aurora 激酶和 lim 激酶分别参与肿瘤细胞分裂和细胞运动。Aurora/LIM 激酶-IN-1 抑制 GBM 增殖和侵袭。Aurora/LIM 激酶-IN-1 是一种很有前途的新型 Aurora/lim 激酶双抑制剂支架，可用于未来 GBM 和潜在其他癌症的药物开发工作。

Aurora/LIM kinase-IN-1

Aurora/LIM kinase-IN-1 Chemical Structure

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生物活性

Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and lim kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future drug development efforts for GBM, and potentially other cancers[1].

分子量

312.37

Formula

C16H20N6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rybin MJ, et al. A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion. Bioorg Med Chem Lett. 2022;61:128614.

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