EGFR-IN-36

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR-IN-36 

EGFR-IN-36 是一种有效的 EGFR 抑制剂，对 EGFR (WT)、HER2 (WT)、HER2 (A775_G776insYVMA) 的 IC50 分别为 19.09 nM、120.01 nM、2.35 nM。EGFR-IN-36 具有用于野生和/或突变EGFR和/或HER2激酶介导的肿瘤研究的潜力。

EGFR-IN-36

EGFR-IN-36 Chemical Structure

CAS No. : 2711105-54-1

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生物活性

EGFR-IN-36 is a potent EGFR inhibitor with IC50s of 19.09 nM, 120.01 nM, 2.35 nM for EGFR (WT), HER2 (WT), HER2 (A775_G776insYVMA), respectively. EGFR-IN-36 has potential for wild and/or mutant EGFR and/or HER2 kinase mediated tumors research[1].

IC50 & Target[1]

EGFR (WT)

19.09 nM (IC50)

HER2(WT)

120.01 nM (IC50)

HER2 (A775_G776insYVMA)

2.35 nM (IC50)

体外研究
(In Vitro)

EGFR-IN-36 (compound 8) inhibits A431 cell (IC50=223.6 nM),A549 cell (IC50=7644.42 nM), H1975 cell (IC50=20.68 nM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

488.97

Formula

C26H25ClN6O2
CAS 号

2711105-54-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yihan Wang, et al. Substituted acrylamide derivatives and their compositions and uses. WO2021185348A1.

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