Butyrolactone I(Synonyms: Olomoucin)

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Butyrolactone I (Synonyms: Olomoucin)

Butyrolactone I 是 CDK1 的 ATP 竞争性抑制剂，是 A.terreus 的次级代谢产物。Butyrolactone I 在非小细胞肺癌、小细胞肺癌和前列腺癌细胞系中具有抗肿瘤作用。

Butyrolactone I(Synonyms: Olomoucin)

Butyrolactone I Chemical Structure

CAS No. : 87414-49-1

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生物活性

Butyrolactone I is an ATP-competitive inhibitor of CDK1 as a secondary metabolite from A. terreus[1]. Butyrolactone I has antitumor effects in non-small cell lung, small cell lung, and prostate cancer cell lines[2].

IC50 & Target

CDK1

 

分子量

424.44

Formula

C24H24O7
CAS 号

87414-49-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nishio K, et al. Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines. Anticancer Res. 1996 Nov-Dec;16(6B):3387-95. P

    [2]. Suzuki M, et al. Butyrolactone I induces cyclin B1 and causes G2/M arrest and skipping of mitosis in human prostate cell lines. Cancer Lett. 1999 Apr 26;138(1-2):121-30.

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