BTK-IN-9

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BTK-IN-9 

BTK-IN-9 是一种可逆的 BTK 抑制剂，在套细胞淋巴瘤细胞中中具有较强的抗增殖活性。BTK-IN-9 特异性地扰乱线粒体膜电位并增加 Z138 细胞中的活性氧水平。BTK-IN-9 还诱导 Z138 细胞中的细胞凋亡。

BTK-IN-9

BTK-IN-9 Chemical Structure

CAS No. : 2361192-21-2

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生物活性

BTK-IN-9 is a reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. BTK-IN-9 specifically disturbs mitochondrial membrane potential and increases reactive oxygen species level in Z138 cells. BTK-IN-9 also induces cell apoptosis in Z138 cells[1].

分子量

481.46

Formula

C25H19N7O4
CAS 号

2361192-21-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ran F, et al. Design and synthesis of novel pyrazolopyrimidine-based derivatives as reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. Med Chem Res, 2022, 31, 594-604.

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