CAY10444(Synonyms: BML-241) | whatman (沃特曼)

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CAY10444 (Synonyms: BML-241)

CAY10444 (BML-241) 是一种 sphingosine-1-phosphate 3 (S1P3) 拮抗剂。CAY10444 在表达 S1P3 受体的 HeLa 细胞中抑制 37% S1P 诱导的 Ca²⁺ 增加。

CAY10444 Chemical Structure

CAS No. : 298186-80-8

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生物活性

CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca²⁺ in HeLa cells expressing S1P3 receptors^[1].

IC₅₀ & Target^[1]

S1PR3

体外研究
(In Vitro)

BML-241 inhibits increases in intracellular Ca²⁺ concentration via P2 receptor or α1A-adrenoceptor stimulation and α1A-adrenoceptor-mediated contraction of rat mesenteric artery, while it does not affect S1P3-mediated decrease of Forskolin-induced cyclic AMP accumulation^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

287.46

Formula

C₁₅H₂₉NO₂S

CAS 号

298186-80-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9.

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