IDO1-IN-15 is a potent IDO1 inhibitor (IC₅₀=127 nM). IDO1-IN-15 has comparable potency against IDO1 enzyme in vitro with Epacadostat^[1].

Cas9-IN-2 is a potent Cas9 inhibitor (IC₅₀=246 μM), Cas9-IN-2 acts by binding to apo-Cas9 to prevent Cas9:gRNA complex formation, which can potentially be applied to modulate and control Cas9 activity in various applications^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

401.19

C₁₃H₁₄BrFN₆O₃

2126853-17-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wu Y, et al. Discovery of novel IDO1 inhibitors targeting the protein’s apo form through scaffold hopping from holo-IDO1 inhibitor. Bioorg Med Chem Lett. 2021;52:128373.