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Pyruvate Carboxylase-IN-2
Pyruvate Carboxylase-IN-2 (compound 29) 是一种有效的丙酮酸羧化酶(pyruvate carboxylase) 抑制剂,在基于细胞裂解物和基于细胞的 PC 活性中,IC50s 分别为 0.065 和 0.097 μM。Pyruvate Carboxylase-IN-2 是毛兰素的天然类似物。Pyruvate Carboxylase-IN-2 抑制 PC 的酶活性,介导人肝细胞癌 (HCC) 的抗癌作用。
Pyruvate Carboxylase-IN-2 Chemical Structure
CAS No. : 1469730-16-2
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生物活性 |
Pyruvate Carboxylase-IN-2 (compound 29) is a potent inhibitor of pyruvate carboxylase (PC) with IC50s of 0.065 and 0.097 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-2 is a natural analog of erianin. Pyruvate Carboxylase-IN-2 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC)[1]. |
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分子量 |
402.39 |
Formula |
C21H22O8 |
CAS 号 |
1469730-16-2 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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