Pyruvate Carboxylase-IN-1 | whatman (沃特曼)

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Pyruvate Carboxylase-IN-1

Pyruvate Carboxylase-IN-1 (compound 37) 是一种有效的丙酮酸羧化酶(pyruvate carboxylase) 抑制剂，在基于细胞裂解物和基于细胞的 PC 活性中，IC₅₀s 分别为 0.204 和 0.104 μM。Pyruvate Carboxylase-IN-1 是毛兰素的天然类似物。Pyruvate Carboxylase-IN-1 抑制 PC 的酶活性，介导人肝细胞癌 (HCC) 的抗癌作用。

Pyruvate Carboxylase-IN-1 Chemical Structure

CAS No. : 70205-50-4

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生物活性	Pyruvate Carboxylase-IN-1 (compound 37) is a potent inhibitor of pyruvate carboxylase (PC) with IC₅₀s of 0.204 and 0.104 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-1 is a natural analog of erianin. Pyruvate Carboxylase-IN-1 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC)^[1].
分子量	242.27
Formula	C₁₅H₁₄O₃
CAS 号	70205-50-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Sheng Y, et al. Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming. J Med Chem. 2022;65(1):460-484.

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