EGFR-IN-27

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

EGFR-IN-27 

EGFR-IN-27 是一种有效的 EGFR 抑制剂,对 EGFR Del, L858R, Del/T790M, L858R/T790M, Del/T790M/C797S, L858R/T790M/C797S 的 IC50 为 <50 nM。

EGFR-IN-27

EGFR-IN-27 Chemical Structure

CAS No. : 2752328-62-2

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生物活性

EGFR-IN-27 is a potent EGFR inhibitor with IC50s of <50 nm for egfr del, l858r, del>[1].

IC50 & Target[1]

EGFRdel19

<50 nM (IC50)

EGFRL858R

<50 nM (IC50)

EGFRL858R/T790M

<50 nM (IC50)

EGFRdel19 T790M C797S

<50 nM (IC50)

EGFR (C797S/T790M/L858R)

<50 nM (IC50)

EGFRdel19 T790M

<50 nM (IC50)

分子量

655.77

Formula

C35H46N9O2P

CAS 号

2752328-62-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Alkenyl pyrimidine compound, preparation method therefor, and application thereof. WO2021249324A1.

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