EGFR-IN-21

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

EGFR-IN-21 

EGFR-IN-21 是一种有效的 EGFR 抑制剂，IC50 为 0.38 nM。EGFR-IN-21 具有抗肿瘤活性。

EGFR-IN-21

EGFR-IN-21 Chemical Structure

CAS No. : 2648206-31-7

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生物活性

EGFR-IN-21 is a potent EGFR inhibtior with an IC50 of 0.38 nM. EGFR-IN-21 has antitumor activity[1].

IC50 & Target[1]

EGFR

0.38 nM (IC50)

体外研究
(In Vitro)

EGFR-IN-21 inhibits HEK293T cells (IC50=951.51 nM) and PC9 EGFR-Del19/T790M/C797S cells (IC50=135.11 nM)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

EGFR-IN-21 (1 mg/kg; IV) has a T1/2 of 3.33 hours, and a Vss of 0.374 L/kg for female CD-1 mouse[1].
EGFR-IN-21 (5 mg/kg;po) has a T1/2 of 3.13 hours, a Cmax of 2077 ng/ml and an AUC of 7542 h·ng/ml[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

759.68

Formula

C36H44BrN10O2P
CAS 号

2648206-31-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lei Liu, et al. Polyaryl compounds as EGFR kinase inhibitors. WO2021104441.

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