NS3694

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

NS3694 

NS3694 是一种二芳基脲化合物，是一种凋亡体抑制剂。NS3694 抑制凋亡小体形成和半胱天冬酶活化。

NS3694

NS3694 Chemical Structure

CAS No. : 426834-38-0

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生物活性

NS3694, a diarylurea compound, is an apoptosome inhibitor. NS3694 inhibits apoptosome formation and caspase activation[1].

体外研究
(In Vitro)

When cell extracts are stimulated with cytochrome c and dATP in the presence of NS3694 (10-100 μM; 120 min), a dose-dependent inhibition of caspase 9, 3, and 7 processing, DFF45/ICAD and PARP cleavage, and DEVDase activity is observed[1].
NS3694 (10-100 μM) inhibits TNF-induced effector caspase activation and apoptosis in MCF-casp3 cells[1].
NS3694 specifically suppresses the cytochrome C-induced formation of apoptosome complex and caspase-9 activation, thus inhibiting the mitochondria-mediated apoptosis. NS3694 inhibits the formation of the apoptosome Apaf-1 by blocking the activation of the initiator caspase-9[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 10 μM, 50 μM, 100 μM
Incubation Time: 120 min
Result: Inhibited cytochrome c- and dATP-induced DEVDase activation and processing of caspases and caspase substrates.

分子量

358.70

Formula

C15H10ClF3N2O3
CAS 号

426834-38-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ulrik Lademann, et al. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex. Mol Cell Biol. 2003 Nov;23(21):7829-37.

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