Sarcosine-15N(Synonyms: N-Methylglycine-15N; Sarcosin-15N)

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Sarcosine-15N (Synonyms: N-Methylglycine-15N; Sarcosin-15N)

Sarcosine-15N (N-Methylglycine-15N) 是带有 15N 标记的 Sarcosine。Sarcosine (N-Methylglycine) 是一种內源性氨基酸,是竞争性的甘氨酸转运蛋白-1 (GlyT1) 抑制剂和甘氨酸受体协同激动剂。Sarcosine 通过增加甘氨酸的浓度增强 NMDA 受体的功能。Sarcosine 通常用于精神分裂症的研究。

Sarcosine-15N(Synonyms: N-Methylglycine-15N;  Sarcosin-15N)

Sarcosine-15N Chemical Structure

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生物活性

Sarcosine-15N (N-Methylglycine-15N) is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

90.09

Formula

C3H715NO2

中文名称

肌氨酸 15N

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

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