APC-6860

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

APC-6860 

APC-6860 是一种胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 抑制剂，对于 uPA、胰蛋白酶的 ki 值为 0.21 和 0.44 μM。APC-6860 对 tPA 与 uPA 的选择性比为 80。APC-6860 对人和鼠尿激酶的 ki 值分别为 0.1 和 0.082 μM。APC-6860 可用于癌症研究。

APC-6860

APC-6860 Chemical Structure

CAS No. : 154628-42-9

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生物活性

APC-6860 is a trypsin-like serine proteases inhibitor with ki values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has ki values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer[1][2].

IC50 & Target[1][2]

uPA

0.21 μM (Ki)

trypsin

0.44 μM (Ki)

tryptase

1.5 μM (Ki)

tPA

16.8 μM (Ki)

thrombin

20 μM (Ki)

factor Xa

30 μM (Ki)

human urokinases

0.1 μM (Ki)

murine urokinases

0.082 μM (Ki)

体外研究
(In Vitro)

APC-6860 (compound 2) inhibits urokinases in MiaPaCa-2 and Lewis Lung Carcinoma cells with IC50s of 1.4 and 3.1 μM, respectively[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

302.13

Formula

C9H7IN2S
CAS 号

154628-42-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Katz BA, et al. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator. Chem Biol. 2000 Apr;7(4):299-312.

    [2]. Klinghofer V, et al. Species specificity of amidine-based urokinase inhibitors. Biochemistry. 2001 Aug 7;40(31):9125-31.

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