L-threo Lysosphingomyelin (d18:1)(Synonyms: L-threo-Sphingosylphosphorylcholine)

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L-threo Lysosphingomyelin (d18:1) (Synonyms: L-threo-Sphingosylphosphorylcholine)

L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) 是一种内源性生物活性鞘脂。L-threo Lysosphingomyelin (d18:1) 是一种有效的 S1P 受体激动剂，对于hS1P1、hS1P3、hS1P2 的 EC50 分别为 19.3、131.8 和 313.3 nM。

L-threo Lysosphingomyelin (d18:1)(Synonyms: L-threo-Sphingosylphosphorylcholine)

L-threo Lysosphingomyelin (d18:1) Chemical Structure

CAS No. : 105615-55-2

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生物活性

L-threo Lysosphingomyelin (d18:1) (L-threo-Sphingosylphosphorylcholine) is an endogenous bioactive sphingolipid. L-threo Lysosphingomyelin (d18:1) is a potent S1P receptor agonist with EC50s of 19.3, 131.8, and 313.3 nM for hS1P1, hS1P3, and hS1P2, respectively[1].

IC50 & Target[1]

S1PR1

19.3 nM (EC50, human)

S1PR3

131.8 nM (EC50, human)

S1PR2

313.3 nM (EC50, human)

分子量

464.62

Formula

C23H49N2O5P
CAS 号

105615-55-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Im DS, et al. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 2001;40(46):14053-14060.

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