Namoline(Synonyms: 萘莫胺) | whatman (沃特曼)

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Namoline (Synonyms: 萘莫胺)

Namoline，一种 γ-pyrone，是选择性、可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂，在 HRP 偶联酶测定中的 IC₅₀ 为 51 μM。Namoline 损害 LSD1 去甲基化酶活性并阻止细胞增殖。Namoline 具有雄激素依赖性前列腺癌研究的潜力。

Namoline Chemical Structure

CAS No. : 342795-11-3

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生物活性	Namoline, a γ-pyrone, is a selective and reversible Lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 of 51 μM in a HRP-coupled enzymatic assay. Namoline impairs LSD1 demethylase activity and blocks cell proliferation. Namoline has the potential for androgen-dependent prostate cancer research^[1].
体外研究 (In Vitro)	Namoline (50 μM; 24, 48, 72 hours) reduces androgen-induced proliferation of LNCaP cells^[1]. Namoline (50 μM) specifically impairs AR agonist R1881-induced (1 nM) demethylation of H3K9me1 and H3K9me2 in LNCaP cells^[1]. Namoline (50 μM) does not affect the enzymatic activities of MAOs under these conditions^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Namoline (0.02 mg;ip; daily) severely blunts xenograft tumor growth in nude mice with LNCaP cells^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	293.58
Formula	C₁₀H₃ClF₃NO₄
CAS 号	342795-11-3
中文名称	萘莫胺
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Dominica Willmann, et al. Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer. 2012 Dec 1;131(11):2704-9.

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