BAZ1A-IN-1

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BAZ1A-IN-1  纯度: 99.84%

BAZ1A-IN-1 是一种有效的 BAZ1A（含溴结构域蛋白）抑制剂。 BAZ1A-IN-1 对 BAZ1A 溴结构域的 KD 值为 0.52 μM。BAZ1A-IN-1 对高表达 BAZ1A 的癌细胞系显示出良好的抗生存活性，但对低表达 BAZ1A 的癌细胞表现出弱活性或无活性。

BAZ1A-IN-1

BAZ1A-IN-1 Chemical Structure

CAS No. : 941521-45-5

规格 价格 是否有货 数量
5 mg ￥3000 In-stock
10 mg ￥4800 In-stock
50 mg ￥14500 In-stock
100 mg   询价  
200 mg   询价  

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BAZ1A-IN-1 相关产品

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生物活性

BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].

IC50 & Target

BAZ1A[1]
体外研究
(In Vitro)

BAZ1A-IN-1 (Cpd-2) (0.015-100  μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: THP-10 (leukemia), ZR-75-30 (breast cancer), BT474 (breast cancer), H1975 (lung cancer) cells
Concentration: 0.015-100  μM
Incubation Time: 96 hours
Result: Significantly inhibited the viability activity in four cancer cell lines which all expressed high levels of BAZ1A.

分子量

340.36

Formula

C16H12N4O3S
CAS 号

941521-45-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 25 mg/mL (73.45 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9381 mL 14.6903 mL 29.3807 mL
5 mM 0.5876 mL 2.9381 mL 5.8761 mL
10 mM 0.2938 mL 1.4690 mL 2.9381 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745.

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