Dimethyl-F-OICR-9429-COOH

发表于由

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Dimethyl-F-OICR-9429-COOH 

Dimethyl-F-OICR-9429-COOH 是一种靶蛋白 WD40 重复域蛋白 5 (WDR5) 的配体，可用于 PROTAC 的合成。详细信息请参考专利文献 WO2019246570A1 中的中间体 19。

Dimethyl-F-OICR-9429-COOH

Dimethyl-F-OICR-9429-COOH Chemical Structure

CAS No. : 2407458-49-3

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生物活性

Dimethyl-F-OICR-9429-COOH a ligand for WD40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1 intermediate 19. Dimethyl-F-OICR-9429-COOH can be used in the synthesis of PROTACs[1].

IC50 & Target

Ligand for Target Protein for PROTAC[1]
体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

546.51

Formula

C27H26F4N4O4
CAS 号

2407458-49-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation/disruption compounds and methods of use. WO2019246570A1.

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