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SD-1029
SD-1029 是一种 JAK2/STAT3 抑制剂。SD-1029 抑制 STAT3 核易位。SD-1029 抑制 JAK2 磷酸化，从而抑制 STAT3 激活。
SD-1029 Chemical Structure
CAS No. : 118372-34-2
| 规格 |
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是否有货 |
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| 100 mg |
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询价 |
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| 250 mg |
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询价 |
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| 500 mg |
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询价 |
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* Please select Quantity before adding items.
| 生物活性 |
SD-1029 is a JAK2/STAT3 inhibitor[1]. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation[2].
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| IC50 & Target[1] |
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体外研究
(In Vitro) |
SD-1029 (10 μM) inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells[1].
SD-1029 (5 and 10 μM; 24 hours) inhibits cell growth and induces apoptosis in OVCAR8TR ovarian cancer cells[1].
SD-1029 (10 μM; 24 hours) suppresses p-Stat3 levels in human breast and ovarian cancer cell lines[1].
SD-1029 inhibits not only JAK2 phosphorylation, but also the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression[2].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[1]
| Cell Line: |
OVCAR8TR ovarian cancer cells |
| Concentration: |
5 and 10 μM |
| Incubation Time: |
24 hours |
| Result: |
Down-regulated cell proliferation, and induced apoptotic cell death.
Treatment resulted in a marked, 20-fold induction of apoptosis in the OVCAR8TR cells that express constitutively activated Stat3. |
Western Blot Analysis[1]
| Cell Line: |
MDA-MB-468 and MDA435 (breast cancer), OV1063 (ovarian cancer), and the paclitaxel-resistant ovarian cancer daughter lines, SKOV-3TR and OVCAR8TR. |
| Concentration: |
10 μM |
| Incubation Time: |
24 hours |
| Result: |
Led to reduced levels of pStat3. |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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| 参考文献 |
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[1]. Zhenfeng Duan, et al. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res. 2006 Nov 15;12(22):6844-52.
[2]. Nor Fazila Che Mat, et al. Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. J Interferon Cytokine Res. 2011 Apr;31(4):363-71.
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