SKI-I

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SKI-I 

SKI-I 是一种有效和选择性的人鞘氨醇激酶 (SK) 抑制剂，抑制 ST-hSK 的 IC50 值为 1.2 μM。SKI-I 还抑制 hERK2 (IC50=11 μM)。SKI-I 在肿瘤细胞系中诱导细胞凋亡。

SKI-I

SKI-I Chemical Structure

CAS No. : 306301-68-8

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生物活性

SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2].

IC50 & Target

IC50: 1.2 μM (ST-hSK); 11 μM (hERK2)[1]
体外研究
(In Vitro)

SKI-I (Compound I; 5 μg/mL) inhibits SK activity by 99%[1].
SKI-I (10 μM; 24 h) induces the apoptosis of T24 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

406.44

Formula

C25H18N4O2
CAS 号

306301-68-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. French KJ, et, al. Discovery and evaluation of inhibitors of human sphingosine kinase. Cancer Res. 2003 Sep 15;63(18):5962-9.

    [2]. Sharma AK, et, al. Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. Eur J Med Chem. 2010 Sep;45(9):4149-56.

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