HA-100 hydrochloride

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HA-100 hydrochloride 

HA-100 hydrochloride 是一种有效的蛋白激酶抑制剂，抑制 PKG，PKA，PKC 和 MLC 激酶的 IC50 值分别为 4 μM、8 μM、12 μM 和 240 μM。HA-100 hydrochloride 也用作 ROCK 抑制剂。

HA-100 hydrochloride

HA-100 hydrochloride Chemical Structure

CAS No. : 141543-63-7

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HA-100 hydrochloride 的其他形式现货产品:

HA-100

生物活性

HA-100 hydrochloride is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor[1][2].

IC50 & Target[1]

PKG

4 μM (IC50)

PKA

8 μM (IC50)

PKC

12 μM (IC50)

MLCK

240 μM (IC50)

ROCK

 

体外研究
(In Vitro)

HA-100 hydrochloride inhibits MLC-kinase and PKC competitively with respect to ATP, with Kis of 61 and 6.5 μM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

313.80

Formula

C13H16ClN3O2S
CAS 号

141543-63-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hagiwara M, et, al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32(1):7-12.

    [2]. Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6(3):e17557.

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