Nemorosone

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Nemorosone 

Nemorosone 是 Clusia rosea 树脂的主要成分。Nemorosone 对癌细胞有抗增殖作用。Nemorosone 诱导 HT-29 和 LoVo 细胞凋亡 (apoptosis)。

Nemorosone

Nemorosone Chemical Structure

CAS No. : 351416-47-2

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生物活性

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].

IC50 & Target

apoptosis[1]
体外研究
(In Vitro)

Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HT-29 and LoVo cells
Concentration: 0-50 μM
Incubation Time: 24-72 h
Result: Inhibited the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Increased the percentage of G0/G1 phase cells.

Apoptosis Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Induced apoptosis in both cell lines.

体内研究
(In Vivo)

Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor[2]
Dosage: 50 mg/kg
Administration: Daily i.p. injections for 28 days
Result: Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2].

分子量

502.68

Formula

C33H42O4
CAS 号

351416-47-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Frión-Herrera Y, Gabbia D, Scaffidi M, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21(5):1827. Published 2020 Mar 6.

    [2]. Wolf RJ, et al. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One. 2013;8(9):e74555. Published 2013 Sep 5.

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