Nemorosone

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Nemorosone 

Nemorosone 是 Clusia rosea 树脂的主要成分。Nemorosone 对癌细胞有抗增殖作用。Nemorosone 诱导 HT-29 和 LoVo 细胞凋亡 (apoptosis)。

Nemorosone

Nemorosone Chemical Structure

CAS No. : 351416-47-2

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生物活性

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].

IC50 & Target

apoptosis[1]
体外研究
(In Vitro)

Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HT-29 and LoVo cells
Concentration: 0-50 μM
Incubation Time: 24-72 h
Result: Inhibited the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Increased the percentage of G0/G1 phase cells.

Apoptosis Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Induced apoptosis in both cell lines.

体内研究
(In Vivo)

Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor[2]
Dosage: 50 mg/kg
Administration: Daily i.p. injections for 28 days
Result: Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2].

分子量

502.68

Formula

C33H42O4
CAS 号

351416-47-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Frión-Herrera Y, Gabbia D, Scaffidi M, et al. The Cuban Propolis Component Nemorosone Inhibits Proliferation and Metastatic Properties of Human Colorectal Cancer Cells. Int J Mol Sci. 2020;21(5):1827. Published 2020 Mar 6.

    [2]. Wolf RJ, et al. In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts. PLoS One. 2013;8(9):e74555. Published 2013 Sep 5.

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