Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Thio-ITP (Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

Thio-ITP (6-Thioinosine 5′-triphosphate) 是一种 RNA 聚合酶 (RNA polymerase) 活性的竞争性抑制剂。Thio-ITP 对聚合酶具有高表观亲和力，RNA 聚合酶 I 的 Ki 值为 40.9 μM，RNA聚合酶 II 的 Ki 值为 38.0 μM。

Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5

Thio-ITP Chemical Structure

CAS No. : 27652-34-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].

IC50 & Target[1]

RNA polymerase I

40.9±11.0 μM (Ki)

RNA polymerase II

38.0±6.47 μM (Ki)

体外研究
(In Vitro)

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

524.23

Formula

C10H15N4O13P3S
CAS 号

27652-34-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务