Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

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Thio-ITP (Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5′-triphosphate; 6-Thio-ITP)

Thio-ITP (6-Thioinosine 5′-triphosphate) 是一种 RNA 聚合酶 (RNA polymerase) 活性的竞争性抑制剂。Thio-ITP 对聚合酶具有高表观亲和力，RNA 聚合酶 I 的 Ki 值为 40.9 μM，RNA聚合酶 II 的 Ki 值为 38.0 μM。

Thio-ITP(Synonyms: 6-Thioinosine 5′-triphosphate; 6-Mercaptopurine-riboside-5

Thio-ITP Chemical Structure

CAS No. : 27652-34-2

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生物活性

Thio-ITP (6-Thioinosine 5′-triphosphate) is an RNA polymerase activity competitive inhibitor. Thio-ITP has a high apparent affinity for the polymerases (RNA polymerase I Ki: 40.9 μM; RNA polymerase II Ki: 38.0 μM)[1].

IC50 & Target[1]

RNA polymerase I

40.9±11.0 μM (Ki)

RNA polymerase II

38.0±6.47 μM (Ki)

体外研究
(In Vitro)

Thio-ITP inhibits both endogenous and exogenous DNA-directed RNA synthesis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

524.23

Formula

C10H15N4O13P3S
CAS 号

27652-34-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kawahata RT, Chuang LF, Holmberg CA, Osburn BI, Chuang RY. Inhibition of human lymphoma DNA-dependent RNA polymerase activity by 6-mercaptopurine ribonucleoside triphosphate. Cancer Res. 1983 Aug;43(8):3655-9.

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