S-(N-PhenethylthiocarbaMoyl)-L-cysteine(Synonyms: PEITC-Cys)

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S-(N-PhenethylthiocarbaMoyl)-L-cysteine (Synonyms: PEITC-Cys)

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) 是一种抗癌物质 (anticarcinogenic)，具有抗白血病活性。S-(N-PhenethylthiocarbaMoyl)-L-cysteine 抑制 HL60 细胞的 DNA 合成。S-(N-PhenethylthiocarbaMoyl)-L-cysteine 是 P450 抑制剂。

S-(N-PhenethylthiocarbaMoyl)-L-cysteine(Synonyms: PEITC-Cys)

S-(N-PhenethylthiocarbaMoyl)-L-cysteine Chemical Structure

CAS No. : 53330-02-2

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生物活性

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys), an anticarcinogenic agent, has antileukemic activity. S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells[1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is a P450 inhibitor[2].

IC50 & Target

DNA Synthesis[1]; P450[2]
体外研究
(In Vitro)

S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits cell growth of HL60 cell (GC50=336 nM)[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine inhibits DNA synthesis in HL60 cells (IC50=6.47 μM)[1].
S-(N-PhenethylthiocarbaMoyl)-L-cysteine induced DNA fragmentation in HL 60 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HL60 cells
Concentration: 0.1-10 μM
Incubation Time: 48 hours
Result: Inhibited the cell growth with a GC50 value of 336 nM.

Cell Proliferation Assay[1]

Cell Line: HL60 cells
Concentration: 4 μM
Incubation Time: 0, 20, 40, 60, 80, 100 hours
Result: Inhibited the cell growth.

分子量

284.40

Formula

C12H16N2O2S2
CAS 号

53330-02-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Adesida A, Edwards LG, Thornalley PJ. Inhibition of human leukaemia 60 cell growth by mercapturic acid metabolites of phenylethyl isothiocyanate. Food Chem Toxicol. 1996 Apr;34(4):385-92.

    [2]. Conaway CC, et al. Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. Chem Res Toxicol. 2001 Sep;14(9):1170-6.

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