15-Deoxy-Δ-12,14-prostaglandin J2-d4(Synonyms: 15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

15-Deoxy-Δ-12,14-prostaglandin J2-d4 (Synonyms: 15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4)

15-Deoxy-Δ-12,14-prostaglandin J2-d4 (15d-PGJ2-d4) 是 15-Deoxy-Δ-12,14-prostaglandin J2 的氘代物。15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) 是一种环戊烯酮前列腺素和 PGD2 的代谢产物。15-Deoxy-Δ-12,14-prostaglandin J2 是一种选择性的 PPARγ (EC50 为 2 µM) 和共价的 PPARδ 激动剂。15-Deoxy-Δ-12,14-prostaglandin J2 促进 C3H10T1/2 成纤维细胞向脂肪细胞的有效分化，EC50 为 7 μM。

15-Deoxy-Δ-12,14-prostaglandin J2-d4(Synonyms: 15d-PGJ2-d4; 15-Deoxy-Δ12,14-PGJ2-d4)

15-Deoxy-Δ-12,14-prostaglandin J2-d4 Chemical Structure

CAS No. : 1542166-82-4

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生物活性

15-Deoxy-Δ-12,14-prostaglandin J2-d4 (15d-PGJ2-d4) is the deuterium labeled 15-Deoxy-Δ-12,14-prostaglandin J2. 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ (EC50 of 2 µM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC50 of 7 μM[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

320.46

Formula

C20H24D4O3
CAS 号

1542166-82-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Reddy AT, et al. Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor δ as a Novel Target for Covalent Modification by 15-Deoxy-Δ12,14-prostaglandin J2. CS Chem Biol. 2018 Dec 21;13(12):3269-3278.

    [3]. Kliewer SA1, et al. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813-9.

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