Leukotriene B4-d4(Synonyms: LTB4-d4; 5(S),12(R)-DiHETE-d4)

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Leukotriene B4-d4 (Synonyms: LTB4-d4; 5(S),12(R)-DiHETE-d4)

Leukotriene B4-d4 (LTB4-d4) 是 Leukotriene B4 的氘代物。Leukotriene B4 (LTB4) 是白细胞最有效的化学诱导剂和激活剂之一，参与多种炎症性疾病。Leukotriene B4 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。

Leukotriene B4-d4(Synonyms: LTB4-d4; 5(S),12(R)-DiHETE-d4)

Leukotriene B4-d4 Chemical Structure

CAS No. : 124629-74-9

规格 是否有货
25 μg 询价

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生物活性

Leukotriene B4-d4 (LTB4-d4) is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

340.49

Formula

C20H28D4O4
CAS 号

124629-74-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

    [3]. S.WCrooks, et al. Leukotriene B4. The International Journal of Biochemistry & Cell Biology Volume 30, Issue 2, 27 March 1998, Pages 173-178.

    [4]. Takehiko Yokomizo, et al. Leukotriene B4: Metabolism and Signal Transduction. Archives of Biochemistry and Biophysics Volume 385, Issue 2, 15 January 2001, Pages 231-241.

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