Catechin-13C3(Synonyms: (+)-Catechin-13C3; Cianidanol-13C3; Catechuic acid-13C3)

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Catechin-13C3 (Synonyms: (+)-Catechin-13C3; Cianidanol-13C3; Catechuic acid-13C3)

Catechin-13C3 ((+)-Catechin-13C3) 是一种 13C 标记的 Catechin。Catechin ((+)-Catechin) 抑制环加氧酶-1 (COX-1) , IC50 为 1.4 μM。

Catechin-13C3(Synonyms: (+)-Catechin-13C3; Cianidanol-13C3; Catechuic acid-13C3)

Catechin-13C3 Chemical Structure

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生物活性

Catechin-13C3 ((+)-Catechin-13C3) is the 13C-labeled Catechin. Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

289.21

Formula

C1213C3H10O6
中文名称

儿茶素 13C3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Waffo-Téguo P, et al. Potential cancer-chemopreventive activities of wine stilbenoids and flavans extracted from grape (Vitis vinifera) cell cultures. Nutr Cancer. 2001;40(2):173-9.

    [3]. Cheruku SP, et al. Catechin ameliorates doxorubicin-induced neuronal cytotoxicity in in vitro and episodic memory deficit in in vivo in Wistar rats. Cytotechnology. 2018 Feb;70(1):245-259.

    [4]. Alshatwi AA. Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis. J Exp Clin Cancer Res. 2010 Dec 17;29:167.

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