5′-Methylthioadenosine-13C6(Synonyms: ‘-(Methylthio)-5′-deoxyadenosine-13C6; 5′-Deoxy-5′-(methylthio)adenosine-13C6; 5′-S-Methyl-5’-thioadenosine-13C6)

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5′-Methylthioadenosine-13C6 (Synonyms: ‘-(Methylthio)-5′-deoxyadenosine-13C6; 5′-Deoxy-5′-(methylthio)adenosine-13C6; 5′-S-Methyl-5’-thioadenosine-13C6)

5′-Methylthioadenosine-13C6 是一种 13C 标记的 5′-Methylthioadenosine。5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) 是由 S-腺苷蛋氨酸 (SAM) 在多胺合成过程中生成的核苷。5′-Methylthioadenosine 通过抑制肿瘤细胞增殖、侵袭和诱导细胞凋亡 (apoptosis) 来抑制肿瘤，同时控制肿瘤组织的炎症微环境。5′-Methylthioadenosine 及其相关化合物对肿瘤发生具有显着的调节作用。

5

5′-Methylthioadenosine-13C6 Chemical Structure

CAS No. : 2421187-73-5

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生物活性

5′-Methylthioadenosine-13C6 is the 13C-labeled 5′-Methylthioadenosine. 5′-Methylthioadenosine (5′-(Methylthio)-5′-deoxyadenosine) is a nucleoside generated from S-adenosylmethionine (SAM) during polyamine synthesis[1]. 5′-Methylthioadenosine suppresses tumors by inhibiting tumor cell proliferation, invasion, and the induction of apoptosis while controlling the inflammatory micro-environments of tumor tissue. 5′-Methylthioadenosine and its associated materials have striking regulatory effects on tumorigenesis[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

303.29

Formula

C513C6H15N5O3S
CAS 号

2421187-73-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Tang Y, et al. 5′-Methylthioadenosine attenuates ischemia reperfusion injury after liver transplantation in rats. Inflammation. 2014;37(5):1366-1373.

    [3]. Li Y, et al. 5′-Methylthioadenosine and Cancer: old molecules, new understanding. J Cancer. 2019;10(4):927-936.

    [4]. Tang B, et al. Specific Targeting of MTAP-Deleted Tumors with a Combination of 2′-Fluoroadenine and 5′-Methylthioadenosine. Cancer Res. 2018;78(15):4386-4395.

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