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Thalidomide-Piperazine-Piperidine hydrochloride
Thalidomide-Piperazine-Piperidine hydrochloride 是一种合成的E3连接酶-配体-连接物偶联物。Thalidomide-Piperazine-Piperidine hydrochloride 包含基于 Thalidomide 的 cereblon 配体和用于 PROTAC 的连接子。
Thalidomide-Piperazine-Piperidine hydrochloride Chemical Structure
CAS No. : 2599846-44-1
| 规格 | 是否有货 | ||
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| 100 mg | 询价 | ||
| 250 mg | 询价 | ||
| 500 mg | 询价 |
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| 生物活性 |
Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. |
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| IC50 & Target[1] |
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| 体外研究 (In Vitro) |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
461.94 |
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| Formula |
C22H28ClN5O4 |
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| CAS 号 |
2599846-44-1 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 溶解性数据 |
In Vitro:
H2O : 33.33 mg/mL (72.15 mM; Need ultrasonic) DMSO : 3.6 mg/mL (7.79 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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| 参考文献 |
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