上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
ALK-IN-12
ALK-IN-12 是一种有效且具有口服活性的 ALK 抑制剂,IC50 为 0.18 nM。ALK-IN-12 还抑制 IGF1R 和 InsR (IC50=20.3 和 90.6 nM)。具有抗肿瘤活性。
ALK-IN-12 Chemical Structure
CAS No. : 1197958-53-4
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100 mg | 询价 | ||
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500 mg | 询价 |
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生物活性 |
ALK-IN-12 is a potent and orally active ALK inhibitor with an IC50 of 0.18 nM. ALK-IN-12 also inhibits IGF1R and InsR (IC50=20.3 and 90.6 nM). Antitumor activities[1]. |
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体外研究 (In Vitro) |
ALK-IN-12 (compound 11e) effectively inhibits viability of the Karpas-299 ALCL cell line with an IC50 of 28.3 nM[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
ALK-IN-12 (10-50 mg/kg; orally; once daily for 13 consecutive days) shows dose-dependent antitumor activity[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
500.96 |
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Formula |
C24H30ClN6O2P |
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CAS 号 |
1197958-53-4 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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