SB 202190 hydrochloride

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

SB 202190 hydrochloride 

SB 202190 hydrochloride 是选择性的 p38 MAPK 抑制剂，抑制 p38α 和 p38β2 的 IC50 分别为 50 nM 和 100 nM。SB 202190 hydrochloride 与重组人活性 p38 激酶的 ATP 袋结合，Kd 值为 38 nM。SB 202190 hydrochloride 具有抗癌活性。SB202190 hydrochloride诱导自噬 (autophagy)。

SB 202190 hydrochloride

SB 202190 hydrochloride Chemical Structure

CAS No. : 350228-36-3

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SB 202190 hydrochloride 的其他形式现货产品:

SB 202190

生物活性

SB 202190 hydrochloride is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity[1][2]. SB202190 hydrochloride induces autophagy[3].

IC50 & Target[1]

p38α

50 nM (IC50)

p38β2

100 nM (IC50)

体外研究
(In Vitro)

SB 202190 (0-10 μM; 0-72 hours) hydrochloride attenuates growth of a subgroup of CRC cell lines such as RKO, CACO2 and SW480 in a dose- and time-dependent manner[1].
SB 202190 hydrochloride strongly inhibited colony formation and anchorage-independent growth (10 μM for 7-10 days) and elevated apoptotic cell death (10 μM for 72 h) in this same subset of CRC lines (RKO, CACO2 and SW480)[2].
In RKO, CACO2 and SW480 cells, SB 202190 (10 μM; 2 hours) hydrochloride abrogates phosphorylation of S6K1(T389) and S6(S235/236), but not AKT(S473), indicating that p38i selectively blocks mTORC1 signaling[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

SB 202190 (5 mg/kg; intraperitoneal injection; daily for 10-12 days) hydrochloride shows inhibition of tumor cell survival and tumor growth[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

367.80

Formula

C20H15ClFN3O
CAS 号

350228-36-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Davies SP, et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.

    [2]. Yang S, et al. Protective effects of p38 MAPK inhibitor SB202190 against hippocampal apoptosis and spatial learning and memory deficits in a rat model of vascular dementia. Biomed Res Int. 2013;2013:215798.

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