上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
JGB1741 (Synonyms: ILS-JGB-1741)
JGB1741 (ILS-JGB-1741) 是一种有效且特异性的 SIRT1 活性抑制剂,IC50 为 ~15 μM。JGB1741 对 SIRT2 和 SIRT3 具有弱的抑制作用,IC50>100 μM。JGB1741 通过调节 Bax/Bcl2 比率、细胞色素 c 释放和 PARP 裂解来增加乙酰化 p53 水平,导致 p53 介导的细胞凋亡。JGB1741 具有用于乳腺癌研究的潜力。
JGB1741 Chemical Structure
CAS No. : 1256375-38-8
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生物活性 |
JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC50 of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC50>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
JGB1741 (ILS-JGB-1741; 1-10000 nM; 24 h) inhibits MDA-MB 231 cell proliferation[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[1]
Apoptosis Analysis[1]
Cell Cycle Analysis[1]
Western Blot Analysis[1]
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分子量 |
440.56 |
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Formula |
C27H24N2O2S |
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CAS 号 |
1256375-38-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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