Indicine N-oxide-d7(Synonyms: (+)-Indicine N-oxide-d7; NSC 132319-d7)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Indicine N-oxide-d7 (Synonyms: (+)-Indicine N-oxide-d7; NSC 132319-d7)

Indicine N-oxide-d7 ((+)-Indicine N-oxide-d7) 是 Indicine N-oxide 的氘代物。Indicine N-oxide (NSC 132319)，一种吡咯里西定生物碱，抗癌试剂 (antitumor agent) 可用于儿科癌症和实体瘤研究。

Indicine N-oxide-d7(Synonyms: (+)-Indicine N-oxide-d7; NSC 132319-d7)

Indicine N-oxide-d7 Chemical Structure

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生物活性

Indicine N-oxide-d7 ((+)-Indicine N-oxide-d7) is the deuterium labeled Indicine N-oxide. Indicine N-oxide (NSC 132319), a pyrrolizidine alkaloid, is an antitumor agent for pediatric cancer and solid tumors research[1].
体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

322.41

Formula

C15H18D7NO6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. V M Whitehead, et al. Phase I trial of indicine-N-oxide in children with leukemia and solid tumors: a Pediatric Oncology Group study. Cancer Chemother Pharmacol. 1990;26(5):377-9.

    [3]. J S Kovach, et al. Toxicity and pharmacokinetics of a pyrrolizidine alkaloid, indicine N-oxide, in humans. Cancer Res. 1979 Nov;39(11):4540-4.

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