N-Methyl Pemetrexed-d3

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N-Methyl Pemetrexed-d3 

N-Methyl Pemetrexed-d3 是 N-Methyl pemetrexed 的氘代物。N-Methyl pemetrexed 是 Pemetrexed 的一种杂质。N-Methyl pemetrexed 是一种抗叶酸细胞毒剂，可用于癌症研究。

N-Methyl Pemetrexed-d3

N-Methyl Pemetrexed-d3 Chemical Structure

CAS No. : 2714410-41-8

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生物活性

N-Methyl Pemetrexed-d3 is the deuterium labeled N-Methyl pemetrexed. N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

444.46

Formula

C21H20D3N5O6
CAS 号

2714410-41-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Warner A, et, al. Development of a purity control strategy for pemetrexed disodium and validation of associated analytical methodology. J Pharm Biomed Anal. 2015 Feb;105:46-54.

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