Senecionine N-oxide-d3

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Senecionine N-oxide-d3 

Senecionine N-oxide-d3 是 Senecionine N-oxide 的氘代物。Senecionine n-oxide 是千里光寻常型根部培养物中吡咯烷核生物碱生物合成的主要产物。Senecionine N-oxide 具有抗肿瘤活性。

Senecionine N-oxide-d3

Senecionine N-oxide-d3 Chemical Structure

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生物活性

Senecionine N-oxide-d3 is the deuterium labeled Senecionine N-oxide. Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

354.41

Formula

C18H22D3NO6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Thomas Hartmann, et al. Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Phytochemistry, Volume 26, Issue 6, 1987, Pages 1639-1643

    [3]. Kupchan SM, et al. Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. J Pharm Sci. 1967 Apr;56(4):541-3.

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