N-Acetyltyramine-d4 | whatman (沃特曼)

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N-Acetyltyramine-d4

N-Acetyltyramine-d4 是 N-Acetyltyramine 的氘代物。N-Acetyltyramine 是溶藻弧菌 M3-10 产生的群体感应抑制剂 (QSI) 化合物。N-Acetyltyramine 能抑制 C. violaceum ATCC 12472 的群体感应 (QS)。N-Acetyltyramine 逆转阿霉素耐药白血病 P388 细胞的耐药性。

N-Acetyltyramine-d4 Chemical Structure

CAS No. : 2733717-28-5

规格		是否有货
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生物活性	N-Acetyltyramine-d4 is the deuterium labeled N-Acetyltyramine. N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	183.24
Formula	C₁₀H₉D₄NO₂
CAS 号	2733717-28-5
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Reina JC, et al. A Quorum-Sensing Inhibitor Strain of Vibrio alginolyticus Blocks Qs-Controlled Phenotypes in Chromobacterium violaceum and Pseudomonas aeruginosa. Mar Drugs. 2019;17(9):494. Published 2019 Aug 24. [3]. Kunimoto S, et al. Reversal of resistance by N-acetyltyramine or N-acetyl-2-phenylethylamine in doxorubicin-resistant leukemia P388 cells. J Antibiot (Tokyo). 1987;40(11):1651-1652.

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