Palbociclib-d4 hydrochloride(Synonyms: PD 0332991-d4 hydrochloride)

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Palbociclib-d4 hydrochloride (Synonyms: PD 0332991-d4 hydrochloride)

Palbociclib-d4 (PD 0332991-d4) hydrochloride 是 Palbociclib hydrochloride 的氘代物。Palbociclib (PD 0332991) hydrochloride 是选择性的 CDK4 和 CDK6 抑制剂，IC50 分别为11 nM，16 nM。Palbociclib 有潜力用于 ER 阳性和 HER2 阴性乳腺癌的研究。

Palbociclib-d4 hydrochloride(Synonyms: PD 0332991-d4 hydrochloride)

Palbociclib-d4 hydrochloride Chemical Structure

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生物活性

Palbociclib-d4 (PD 0332991-d4) hydrochloride is the deuterium labeled Palbociclib hydrochloride. Palbociclib (PD 0332991) is a selective CDK4 and CDK6 inhibitor with IC50s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

488.02

Formula

C24H26D4ClN7O2
中文名称

帕布昔利布 d4 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.

    [3]. Katsumi Y, et al. Sensitivity of malignant rhabdoid tumor cell lines to PD 0332991 is inversely correlated with p16 expression. Biochem Biophys Res Commun, 2011, 413(1), 62-68.

    [4]. Goel S, et al. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017 Aug 24;548(7668):471-475.

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