Glycochenodeoxycholic acid-d7 sodium(Synonyms: Chenodeoxycholylglycine-d7 sodium; Sodium glycochenodeoxycholate-d7)

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Glycochenodeoxycholic acid-d7 sodium (Synonyms: Chenodeoxycholylglycine-d7 sodium; Sodium glycochenodeoxycholate-d7)

Glycochenodeoxycholic acid-d7 (Chenodeoxycholylglycine-d7) sodium 是 Glycochenodeoxycholic acid (sodium salt) 的氘代物。Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) 是一种从脱氧鹅胆酸和甘氨酸在肝脏中形成的胆汁盐。它起到洗涤剂的作用,可溶解脂肪吸收,并本身被吸收。Glycochenodeoxy

Glycochenodeoxycholic acid-d7 sodium(Synonyms: Chenodeoxycholylglycine-d7 sodium;  Sodium glycochenodeoxycholate-d7)

Glycochenodeoxycholic acid-d7 sodium Chemical Structure

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生物活性

Glycochenodeoxycholic acid-d7 (Chenodeoxycholylglycine-d7) sodium is the deuterium labeled Glycochenodeoxycholic acid (sodium salt). Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) is a bile acid formed in the liver from chenodeoxycholate and glycine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Glycochenodeoxycholic acid sodium salt (Chenodeoxycholylglycine sodium salt) induces hepatocyte apoptosis[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

478.65

Formula

C26H35D7NNaO5

中文名称

甘氨鹅脱氧胆酸钠 d7 (钠盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Liang S, et al. Effect of quercetin 7-rhamnoside on glycochenodeoxycholic acid-induced L-02 human normal livercell apoptosis. Int J Mol Med. 2013 Aug;32(2):323-30.

    [3]. Gonzalez B, et al. Glycochenodeoxycholic acid (GCDC) induced hepatocyte apoptosis is associated with early modulation of intracellular PKC activity. Mol Cell Biochem. 2000 Apr;207(1-2):19-27.

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