Eicosanedioic acid-d4

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Eicosanedioic acid-d4 

Eicosanedioic acid-d4 是 Eicosanedioic acid 的氘代物。Eicosanedioic acid 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联药物 (ADCs)。Eicosanedioic acid 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

Eicosanedioic acid-d4

Eicosanedioic acid-d4 Chemical Structure

CAS No. : 2733743-68-3

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生物活性

Eicosanedioic acid-d4 is the deuterium labeled Eicosanedioic acid. Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

346.54

Formula

C20H34D4O4
CAS 号

2733743-68-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

    [3]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

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