WDR5-0103-d3(Synonyms: WD-Repeat Protein 5-0103-d3)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

WDR5-0103-d3 (Synonyms: WD-Repeat Protein 5-0103-d3)

WDR5-0103-d3 (WD-Repeat Protein 5-0103-d3) 是 WDR5-0103 的氘代物。WDR5-0103是一个有效的含WD重复序列蛋白5 (WDR5) 选择性拮抗剂, Kd 值为450 nM。

WDR5-0103-d3(Synonyms: WD-Repeat Protein 5-0103-d3)

WDR5-0103-d3 Chemical Structure

CAS No. : 2733719-50-9

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生物活性

WDR5-0103-d3 (WD-Repeat Protein 5-0103-d3) is the deuterium labeled WDR5-0103. WDR5-0103 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist with Kd of 450 nM.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

386.46

Formula

C21H22D3N3O4
CAS 号

2733719-50-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Senisterra G, et al. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem J. 2013 Jan 1;449(1):151-159.

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