L-798106-d6 (CM9-d6) is the deuterium labeled L-798106. L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (K_i=0.3 nM), it also has  micromolar activities at the EP4, EP1 and EP2 receptors with K_i values of 916 nM, >5000 nM and >5000 nM at EP4, EP1 and EP2, respectively^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

542.47

C₂₇H₁₆D₆BrNO₄S

2124771-94-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Juteau H, et al. Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor. Bioorg Med Chem. 2001 Aug;9(8):1977-84.